University Study Finds Isagenix Superior to Leading “Heart Healthy” Diet

September 20, 2012 IsagenixHealth.net

Dr. Krista Varaday
University of Illinois
Chicago College of Applied Sciences

Dr. Krista Varady discusses clinical research on Isagenix products.

The highly anticipated results are in—Isagenix products are superior to a leading “heart healthy” dietary plan for weight loss and visceral fat loss. The manuscript has been submitted to two peer-reviewed journals and is still under review; however, you can read more details about the study on our clinical research summary and marketing flyer.

Krista Varady, Ph.D., the lead investigator of the study, is a prolific researcher at the University of Illinois at Chicago’s College of Applied Sciences with more than 30 peer-reviewed research publications. She has a Ph.D. in nutrition from McGill University—one of the top universities in Canada. Dr. Varady has devoted much of her time to investigating the ability of weight-management strategies to decrease cardiovascular disease risk and is one of the pioneers in research on alternate-day and intermittent fasting.

Dr. Varady’s research was presented in August at the 10th annual Isagenix Celebration in Phoenix. Eager to share the exciting results, Dr. Varady answered questions from Isagenix Chief Science Officer Suk Cho, Ph.D.:

Q: What did you think when you tried Isagenix?

A: I always try things before I make my subjects do it. I used Isagenix for three weeks in January before we began the study. I didn’t want to lose a ton of weight, but I did want to see if I could lose a few pounds with it. The easy of use was great—no dishes at breakfast or lunch; you didn’t even need to have milk at home. I went out and bought a few shake products to compare it to and I’m not sure what you guys do, but the consistency is like a smoothie. The other shakes were clumpy and it made them less appealing.

Q: What else impressed you about Isagenix products?

A: I was impressed by the Cleanse Day and the high-protein IsaLean® Shake. All the ingredients actually seemed wholesome. I had thought the shake would be a high-sugar beverage, but I found it to be really nutritionally complete.

Q: What attracted you to collaborate with Isagenix on research using their products?

A:  The main thing was that Isagenix incorporates fasting while on Cleanse Days. I find that really novel. If you look at other meal-replacement diets, they never really incorporate fasting or cleansing. Usually it is a shake for breakfast and a shake for lunch, but they don’t use all the other products Isagenix uses. I like that it is a multifaceted approach. You are also using supplements that may provide metabolic benefit and protect against free radicals—I thought that was really neat too, but the main thing was that there was a Cleanse Day every week because I am really interested in fasting research.

Q: What can you tell us about the study’s results?

A: Our main finding was that weight loss was actually greater in the Isagenix group. On average they lost 3.9 kg, so that works out to be around 9 pounds or so. Obviously, some lost more and some less, but the Isagenix group lost 3 pounds more on average than the other diet. We also saw those changes with fat mass. With Isagenix, we saw slightly greater reductions (although not significant) in fat mass. Neither group lost a significant amount of lean mass, which is great because you want to maintain your muscle mass to keep your metabolic rate higher and that allows you to burn more calories per hour.

Q: What are the results for visceral fat (fat that surrounds the organs)?

A: Even though it wasn’t statistically significant between groups, we found that there was a much greater reduction in visceral fat in the Isagenix group—about twice as much. They lost 0.7 kg, about 2 pounds. I find that amazing—they lost 2 pounds around their organs—that’s a lot!

Q: What other part of this study’s results do you find most exciting or intriguing?

A: What I found most intriguing at first was the adherence of the Isagenix group; they seemed to adhere better because of the convenience factor of the Isagenix system. Also, the Isagenix group lost more weight and more fat (especially visceral fat); and the blood chemistry looked wonderful.

Q: What other personal observations have you made about the Isagenix products and how they affect subjects?

A: Isagenix people just seemed happier. Also, the satiety (or fullness) aspect; people didn’t feel motivated to binge after a shake or cheat on the diet because they really did find those shakes quite filling, so I was pretty impressed with that. That is the main reason that I am even testing out these diets—to find diets that people will actually do and adhere to over the long term. They liked the taste of the shake and just in terms of the easiness too, they said small things like “there were less dishes to wash” and “for breakfast all you really have to do is keep the blender clean, there’s not that much prep involved and it is a portable system.” But those are actually really important things—if a diet is hard to do, people aren’t going to do it for very long. So making it easy, making it easy to clean up after—all those things add up for long term weight loss.

Q: You had some products left over after the study and people asked you for them, right?

A: Yeah, I had 3 boxes left of the shakes and I have never seen women diving in there, fighting with each other. They were all over each other. Those were gone pretty quickly after we opened them up!

Exercise for Fat Loss

Article by Dr. Michael Colgan of the Colgan Institute:

If you are exercising to lose body fat, you have to be concerned you have too much of it. For many folk that much has taken years to establish. Some have solidified the same, 20, 30, 40 lbs, year after year by yo-yo dieting. It’s not easy to change a body that has got into such a state, but if you follow the rules it works like a charm.

People who don’t like rules may want to just get their head down and bull it out. Boot camps love these folk, telling them “You just have to work your butt off at our level and you will lose the fat.” The science says, “No way”. Others read some social buzz that whole neighbourhoods lost masses of fat by getting together and running (biking, mud-wrestling, swimming in holes in the ice). Not going to work.

Anyone who has run a marathon, an extreme 3-4 hour effort for most of us, knows with disgust they lost negligible body fat doing it. Having measured runners in quite a few marathons, an average person well trained to run a marathon, is lucky to lose a quarter pound of fat. Some folk who stuff with carbs during a marathon, actually gain fat. They may feel like hell at the finish, and be 7 lbs lighter in water weight, because the carbs prevent water absorption from the gut, but their belly rebounds and then some within 24 hours.

One controlled study representative of the science, measured body fat losses accurately in groups of men and women over the whole 20-week training program for a half-marathon. In 20 weeks of fairly intense endurance exercise (80 workouts), the men lost an average of 5.3 lbs of fat. That’s just 4.25 ounces per week of exercise. The women lost an average of only 2.0 lbs. That’s a measly 1.6 ounces of fat loss per week of exercise.(1) 

This negligible loss of body fat with exercise is the usual result, and often gives folk the false belief they are different from everyone else, and just can’t get slim. Yes you can. All you need is the right nutrition and exercise. It’s not rocket science. Here are eight exercise rules to get you started on the right track. Stated briefly, with just a major reference or two, they are grounded in a lot of recent science that I will be covering in future articles. You need to follow them all to get sterling results.

Exercise for Fat Loss-Rule 1 

Get 8 hours sleep a night. The US National Center on Sleep Disorders reports that approximately 90 million Americans currently do not get sound sleep.(2) Children sleep better, so it’s a one in three bet that you have sleep disturbance. If you are overweight, it’s 50/50 that you have poor sleep. Sound sleep is an essential physiological restorative process that programs one-third of your life, and controls much of what happens in the other two-thirds.(3) To cut to the chase, without sound sleep, you cannot effectively exercise or effectively lose body fat. Visceral fat gain, food cravings, insulin disruption, fatigue, your whole hormone cascade, the metabolic syndrome, and many other bodily disorders are driven by disruption of your circadian rhythm.(4) Get your sleep fixed first or you will be unable to effectively exercise or lose fat.

Exercise for Fat Loss- Rule 2 

Exercise on waking to raise your metabolic rate for the whole day. When you wake in the morning, your metabolism is sluggish. Your metabolic rate for the day is then determined by what you do. If you have a lazy day off for example, your metabolic rate will remain low throughout, and you will be on maximum calorie retention from anything you eat. If, however, you exercise on waking, even if it is only a 30 minute walk, it raises your metabolic rate immediately. The rate then remains high for most of the day, and you lower your calorie retention from food. Get in the habit. Do that smidgeon of exercise every day.

Exercise for Fat Loss- Rule 3

Exercise on an empty stomach. Your body takes the easiest route to energy. If you eat before exercise, or start at the juice bar with a smoothie at the gym, your body will use the calories in your gut preferentially to using bodyfat for fuel. A single small “all fruit” smoothie will eliminate any weight loss effect of an hour of exercise after it. And, drinking “energy drinks” while working out is just plain dumb if you want to achieve fat loss. It’s just plain dumb for any exercise goal.(5)

Exercise for fat Loss- Rule 4

Do 20-30 minutes of light aerobic exercise before your workout. When you begin exercising, your body uses mainly sugar for fuel, the glycogen in your muscles, sugar made by gluconeogenesis in the liver, and sugar from food in your gut. (Remember, no eating before exercise) To achieve your goal of using body fat for fuel, you first have to induce hormonal changes to switch to greater fat oxidation. You can do this with light aerobic exercise for 20-30 minutes, such as walking to the gym. You cannot achieve these complex changes by lumbering on the treadmill, as I see some folk do, because, as soon as you begin to pant, signaling a shortage of oxygen, you keep the body stuck in sugar burning mode. A whole workout done with great effort, treadmilling wildly, then rushing from station to station for an hour, uses near zero bodyfat, and exhausts you into the bargain, as it empties the muscles of glycogen. It’s tragic but somehow comical to see people doing this week after week, and losing no fat at all.

Exercise for Fat Loss- Rule 5

Do your workout in the “Fat Burning Zone”. There is much nonsense written about the fat burning zone, as if it’s some magical state that melts fat. It is just a range of exercise intensity where fat use (fat oxidation) settles into a high steady level. Studies have measured this range in all sorts of complex ways involving VO2max and weird and wonderful equations. It also varies somewhat with the individual, and how much exercise you do, and how often. But I can state it pretty simply. 

The fat burning zone is exercise done at 60-70% of your maximum heart rate. If you run at maximum on the treadmill, and get your highest heart rate at 170 beats per minute, then your fat burning zone is 60-70% of that score, that is, about 100-120 beats per minute. At this level of exercise you can still carry on a normal conversation.

First, do your 20-30 minute warm up in the fat burning zone to make the hormonal changes to trigger a higher proportion of fat burning. Then, for a one-hour workout on an empty stomach, keep your heart rate within the same range. Your body will then pull approximately 50% of its energy from body fat. That’s about as good as you can get.

Above or below this range, your body’s use of sugar increases, and it pulls only 20 -30% of its energy from body fat. So, it makes sense to wear a heart rate monitor, and set your fat burning range so that it beeps you automatically if you move out of it.

Exercise for Fat Loss- Rule 6

Build muscle to lose fat. All the gym programs I have seen that concentrate on aerobic exercise have been a failure for fat loss. We measured one aerobics group for a year at Frogs Gym in San Diego. All of the women in the group wanted to lose weight. They actually gained an average of 2.9 lbs of fat while doing an average of three aerobics sessions a week for 12 months.The best form of exercise for fat loss is resistance training that adds muscle to your body. Muscle is moving tissue, fat is not. Over 100 muscles are constantly active just to keep you standing up, and about 200 are merrily using energy just to maintain their tone. Fat hangs limp like jello. Muscle is the engine that uses body fat for fuel. With more muscle, more fat is burned 24 hours a day, even just couch sitting with heavy breathing. In her book Strong Women Stay Slim, Miriam Nelson, a Tufts University researcher, followed a group of women who did a weight loss diet plus resistance training. They lost 44% more fat than those who followed the diet alone. So, put resistance training at the top of your list. 

Exercise for Fat Loss Rule 7

Do weight training that makes you taller and more flexible. We have seen it many times, especially with women. They embrace resistance training in order to lose fat, then do all the wrong stuff. Often they hire trainers who give them bodybuilding exercises, or worse, uni-planar exercises guided by machines with comfy seats, exercises that bear no relation to movements in life. They often turn the posture into a muscle-thickened crouch. Though they can achieve lower body fat because of muscle growth, the unfortunate girls look shorter and fatter. 

One example I saw recently. Under a trainer’s direction, a somewhat overweight girl was vigorously doing deadlifts with a bar and two 45lb weights, 135lbs, about her own weight. Each time she lifted the bar you could see her stomach stick out. She did not realize she was training hard to grow a stuck out gut. 

Also, the heavy weight was pulling her shoulders down and forward, shortening and thickening the muscle connections from the arms to the pectoralis major of the chest. It was growing round shoulders with dumpy arms, about the worst training you can think of for most women, who usually aim to be upright, slim, and elegant. 

Another thing this girl didn’t realise was, if you lift your own body weight from the floor, it immediately compresses your spine and makes you temporarily about an inch shorter. Over a long period, the erector spinae muscles that hold up the spine becomes shorter from that form of training. Bulging stomach, forward-sloping shoulders, dumpy arms, and a shortened spine. Not exactly what most folk want from a weight program to lose fat.

The best resistance training for fat loss (and muscle gain) is free-movement exercises, done standing, exercises that lengthen the spine while contracting the muscles. Overhead cables like we use in the Colgan Power Program are best as they can simulate virtually any free movement in life. The Program was first developed for Olympic athletes at Colorado Springs, so you can bet it’s first class for making people muscular and strong. But it also trains long, lean, flexible muscles. And more than 100 different exercises in it lengthen the spine while contracting the muscles. That should be your aim, a tall, elegant, flexible body that emphasizes the low body fat you have worked so hard in the kitchen to achieve.

Exercise for Fat Loss Rule 8

Get a mentor. You can go it alone, but a mentor adds immensely to any program for any skill. To achieve a great body you need someone who is an example, someone who has the skills, someone who can calm your wavering doubts and unerringly guide you in your quest. 

In my article The Making of Genius, 2005, which has been reprinted and copied innumerable times worldwide, I analysed the components that have produced genius in science, music, and arts. One vital component is the mentors that most geniuses had to develop them throughout their lives. These mentors were all experts in the different fields in which the individuals wanted to excel. They were all folk who had already been there, and had learned to excel at the skills.

Your goal of a great body for life is a difficult one. Most people who try fail repeatedly. You need a personal mentor. What Isagenix offers that no one else can, is hundreds of members who have done what you want to do, and who are on the same lifelong journey, walking the same good talk. 

1. Meijer GA, et al. Body composition and sleeping metabolic rate in response to a 5-month endurance-training programme in adults. Eur J Appl Physiol Occup Physiol. 1991;62(1):18-21.2. US National Center on Sleep Disorders.http://www.nhlbi.nih.gov/about/ncsdr/index.htm. Accessed 15 July 2012.3. Aldabal L, Bahammam AS. Metabolic, endocrine, and immune consequences of sleep deprivation. Open Respir Med J. 2011;5:31-43.4. Maury E, et al. Circadian rhythms and metabolic syndrome: from experimental genetics to human disease. Circ Res. 2010 February 19;106(3): 447–462.5. Van Proeyen K, et al. Beneficial metabolic adaptations due to endurance exercise training in the fasted state. J Appl Physiol. 2011 January; 110(1):236–245.

Kjersti Kote add a 9^th Rule:

Use Isagenix to fuel your body after your workouts! I recently interviewed Dr. Colgan and he said the best time to bring a shake into your body is exactly 30 minutes (not 1 hour or 2 hours) after your workouts. This will assist in leam muscle developement and recovery!

Worn Out from Exercising? Vitamin C to the Rescue!

A new pilot study reveals that taking vitamin C may take the edge off of exercise.  Paired with a drop in heart rate, researchers found that the perceived rate of exertion during exercise fell as vitamin C levels in the body rose.

Exhaustion following physical activity can be a hurdle for dieters trying to walk off excess weight. In the current study, obese subjects supplementing this antioxidant experienced less discomfort during physical activity after just four weeks.

Researchers from Arizona State University recruited 20 moderately obese, sedentary adults looking to lose weight. In conjunction with a low-fat, low-calorie diet, the participants took 500 mg of vitamin C or a placebo for four weeks. At baseline and at the final visit, researchers measured the subjects’ moods, perceived rate of exertion, and fat burning during a 60-minute bout of moderate-intensity exercise.

Over the course of the trial, both groups lost between 8 and 10 pounds simply by cutting calories. While fat oxidation did not change between the vitamin C and control groups, the researchers saw a drop in heart rate of nearly 8 percent (about 11 beats per minute) and a 10 percent decrease in the perceived difficulty of exercise after vitamin C supplementation. Both heart rate and exertion increased marginally in the control group.

The authors explain that “heart rate is a contributing factor to perceived effort, the significant decrease in exercising heart rate noted for the vitamin C participants may have influenced the ratings of perceived exertion.”

_______________________________ 

Reference: Huck CJ, Johnston CS, Beezhold BL, and Swan PD. Vitamin C status and perception of effort during exercise in obese adults adhering toa calorie-reduced diet. Nutrition 2012;1-4. doi:10/1016/j.nut.2012.021

Read more about this study on Isagenix Health.

Glutahione: The Queen of Anti-Aging Process

Article from: Isagenix Health News

What protects your cells from oxidative damage better than vitamin C, vitamin E, beta-carotene, lycopene, or any other antioxidant currently on the market?

The answer is glutathione. This slasher of pro-oxidants and quencher of free radicals is actually made by your cells, for your cells. The glutathione redox system is an antioxidant powerhouse within the body, and consuming certain foods such as whey protein boosts your glutathione levels, and in doing so may preserve your health and delay the onset of old cellular age.

The key to life is sustaining function while efficiently tackling the onslaught of toxins that overwhelm the body. Glutathione is integral in this oxidative balance, as it protects against dangerous oxidative species clamoring to break through the cell’s defenses and is responsible for the renewal of other antioxidant agents. Glutathione is queen in the battle for health and longevity—a protector we must protect. Losing the queen could mean you’re losing the battle.

Biological aging is the result of cellular decline now understood to be due to a combination of oxidative stress and telomere shortening. The health of the cell serves as a junction between biological, cellular, and functional aging. Glutathione wards off damage to cells that, according to the recent scientific literature, accompanies the dysfunction of telomeres and mitochondria that develops over time. 
In addition to environmental, dietary, and psychological stressors that wreak havoc on cells, byproducts of metabolism that are essential to sustain life will also break our bodies down. With living comes aging and the human condition exists in a Catch 22 of sorts.

Glutathione synthesis rapidly decreases as we age. Researchers have found that the elderly have about 50 percent less glutathione in their cells than younger, height- and weight-matched controls (2). Low glutathione levels are not just linked to aging, but also to higher levels of oxidative damage and lower levels of intracellular antioxidants, which are commonly found in aged individuals (3). Glutathione’s actual involvement in the aging process and relationship with chronic disease is unclear. According to researchers, however, glutathione may be the best indicator of functional age.

Synthesized from three different amino acids, glutathione is a tri-peptide. Since it is made by the cell, it would make sense to believe that rate of synthesis is regulated by cells. Fortunately, this is not the case, or at least it is up for debate. Glutathione naturally decreases with age—but so will muscle, collagen, and maybe even cognition. Your antioxidant systems will degrade, and your cells will have a harder time processing toxic loads, unless you enable their defenses. The human body is remarkable in its ability to accept, adapt, and to renew (take advantage!).

Branching out beyond the branched chain amino acids, whey protein is also the best source of the sulfur containing the amino acid cysteine (1). Cysteine, in conjunction with glycine and glutamic acid, are the building blocks for intracellular glutathione. With more cysteine than any other plant and animal protein, undenatured whey protein brings the resources to counter-balance the compression of aging on cell protection.

To illustrate adaptability, older people supplementing with cysteine and glycine increased their rate of glutathione synthesis by 230 percent (2). After just two weeks of supplementing with the glutathione precursors, the subjects obtained an antioxidant status on par with a younger crowd. (To read more about this study, click here.) While these men and women supplemented with individual amino acids, some research suggests that whey protein may actually be a more effective stimulus for dosing up on glutathione (1).

Unfortunately, no one can take candles off their birthday cake, but biological age doesn’t have to have such a fixed rate. The Free Radical Theory of Aging suggests just that—oxidants, radicals, and toxins debilitate cells and deprive us of our youth. Promoting glutathione production is a direct way to reduce the oxidative duress put on cells. Being the sum of our parts, preserving our cellular age should be a key focus for turning back the clock.

References

1. Bounous G and P Gold. The biological activity of undenatured dietary whey proteins: role of glutathione. Clin Invest Med Volume 1991;14:296-309.
2. Sekhar R et al. Deficient synthesis of glutathione underlies oxidative stress in aging can be corrected by dietary cysteine and glycine supplementation. Am J Clni Nutr 2011; 1-7.
3. Kharb S et al. Glutation levels in health and sickness. Indian J  Med Sci 2000;54:52-4.

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